PRBB-CRG Sessions Kivanç Birsoy
26/03/2024
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PRBB-CRG Sessions Kivanç Birsoy
MARIE CURIE
26/03/202412:00MARIE CURIEPRBB-CRG SessionsKivanç BirsoyLaboratory of Metabolic Regulation and Genetics, Rockefeller University"Understanding the role of oxidative metabolism in physiology and cancer"Host: Elvan BökeAbstract:Mitochondria must maintain adequate amounts of metabolites for protective and biosynthetic functions. However, how mitochondria sense the abundance of metabolites and regulate metabolic homeostasis is not well understood. Here, we will discuss glutathione (GSH), a critical redox metabolite in mitochondria, and our identification of a feedback mechanism that controls its abundance through the mitochondrial GSH transporter, SLC25A39. We will additionally discuss methods to identify cellular nutrient transporters.