- Research programme page
Coordinator: Ben Lehner
The research groups in the Systems Biology program cover a wide range of topics: from dynamic gene regulatory networks to systems neuroscience, and employ a wide range of model systems to address these issues, including prokaryotes, cell lines, C. elegans, Drosophila and mice.
Underlying this diversity, however, are the common goals of combining systematic and quantitative data collection, using computational models, going beyond molecular descriptions and arriving at a deeper dynamic understanding of complex biological processes.
To achieve these goals the program is strongly interdisciplinary, comprising an increasing number of physicists, mathematicians and computer scientists, in addition to biologists. In this way the program tackles topics such as: signal transduction, gene regulatory networks, multicellular patterning, chemotaxis, systems neuroscience, the evolution of networks, and the impact of stochastic noise at the whole organism level.
We have strong interactions with the local systems biology groups in the UPF. In particular, we consider two labs as being associated to our program:
- The lab of Jordi Garcia-Ojalvo, who focuses on dynamical systems analysis of various biological phenomena.
- The lab of Lucas Carey, who focuses on analysis of single cell behaviour.
EMBL/CRG SYSTEMS BIOLOGY RESEARCH UNIT
With the formation of the partnership (2006-2016) between EMBL and the Centre for Genomic Regulation (CRG), financed by the Spanish Ministry of Economy, Industry and Competitiveness (MINECO), these institutes were set to advance the understanding of complex biological systems. This partnership combined EMBL's expertise in computational biology with the CRG's know-how in specific areas of genomics and proteomics and allowed to better understand some of the key aspects of human health.
Head of this unit on the campus of the Barcelona Biomedical Research Park was Luis Serrano, also director of the CRG. Research drew on the expertise of various scientific disciplines and spanned the entire range from molecules to cells. The four multidisciplinary groups worked with a variety of research techniques, including RNA interference, biochemical networks and mouse development.