Comparative Genomics

Comparative Genomics

Bioinformatics and Genomics

Comparative Genomics

Group leader
j

Comparative Genomics

Group leader
j


1997-2001
Junior researcher at the Molecular Biology and Biochemistry department at the Universitat de València (www.uv.es)
2001-2005 PhD in Bioinformatics, at CMBI (www.cmbi.ru.nl) and NCMLS (www.ncmls.ru.nl) centres at Nijmegen University (The Netherlands) (www.ru.nl) 
2005-2007 EMBO (www.embo.org) Postdoctoral fellow at the Bioinformatics Department at CIPF (Valencia). (http://bioinfo.cipf.es) 
2007-2008 FIS contracted researcher at the Bioinformatics Department at CIPF (Valencia). (http://bioinfo.cipf.es)  
Since Sept 2008 Junior Group Leader in the Bioinformatics and Genomics Programme, at the CRG (Barcelona) (www.crg.es)
Since 2013 ICREA Research Professor

News

Jaguar genome helps unravel the complex evolution of the big cats (19/07/2017)
An international consortium led by Brazilian university PUCRS and including scientists from seven countries (Brazil, USA, Russia, Ireland, Portugal, Spain and Argentina) reported on July 19th in the journal Science Advances the complete sequence of the jaguar genome, along with in-depth analyses comparing it to all other living big cats (lion, tiger, leopard and snow leopard).

Toni Gabaldón receives the 2017 Margaret Dayhoff Mid-Career Award (06/07/2017)
This award is a recognition to outstanding members of the Society for Molecular Biology and Evolution (SMBE) who are in the midst of their research careers.

MicrobioMx wins the S2B Concept Challenge (27/01/2017)
MicrobioMx, a project led by CRG researchers Toni Gabaldon and Pedro González, wins the Science to Business (S2B) Concept Challenge 2016.

Toni Gabaldón awarded an ERC Consolidator Grant (24/12/2016)
Toni Gabaldón, group leader of the Comparative Genomics laboratory and ICREA research professor at the CRG, has been awarded an ERC Consolidator Grant for his project “Reticulate evolution: patterns and impacts of non-Vertical inheritance in eukaryotic genomes” (RETVOLUTION).

Spanish scientists sequence the genome of the Iberian lynx, the most endangered felid (14/12/2016)
Genomic analysis of the Iberian lynx confirms that it is one of the species with the least genetic diversity among individuals, which means that it has little margin for adaptation.

AdaptNET, the first thematic network to face the challenges of research on adaptation genomics (07/11/2016)
AdaptNET is the first Spanish network of excellence on adaptation genomics. The network, funded by the Ministry of Economy and Competitiveness, is made up of 24 laboratories from 11 research centers in Spain, including the Comparative Genomics group at the CRG, and gathers leading scientists at an international scale.

Decoding the complete genome of the Mediterranean’s most emblematic tree: the olive (28/06/2016)
A team of scientists from three Spanish centers has sequenced, for the first time ever, the complete genome of the olive tree.

Genomics and sensory perception in fungi (27/05/2016)
An international team of researchers sequenced and annotated the genome of two fungi species. Their results shed new light on the evolution of sensory perception in fungi as well as open the door to possible applications on pathogenic control and biofuel production.

CRG researchers contribute to the sequencing of the Turbot genome (09/03/2016)
The first vertebrate to be genetically sequenced in Spain, the Turbot (Scophthalmus maximus), has a much more refined visual system than other fish as it has evolved to adapt to the shortage of light of the seabed. In addition, the fat in its cell membranes are far higher than in other species to withstand the low water temperatures in its habitat.

The mesoamerican bean genome decoded (25/02/2016)
An Ibero-American team of scientists decoded the Mesoamerican variety of the bean genome coinciding with the celebration of the International Year of Pulses, as designated by the United Nations.

On the origin of Eukaryotes - when cells got complex - (03/02/2016)
Researchers at the Centre for Genomic Regulation shed light on a crucial moment in the evolution of life: when cells acquired mitochondria. Their study will be published on February 3rd in Nature. It will be accompanied with a news and views article highlighting its importance.

Summary

Our research interests are focused around the use of comparative genomics and phylogenomics to study the origin, evolution and function of complex biological systems. This includes understanding how specific biochemical pathways, protein complexes or cellular organelles emerged and evolved as well as using this evolutionary information to gain insight into their function.

Through collaborations with experimental groups we apply comparative genomics to discover new mechanisms and genes involved in interesting processes, especially those of clinical relevance (see lines of research). On the technical side, our work often involves the development of new bioinformatics tools and algorithms that we make available to the community.

You can have more details here.
http://gabaldonlab.cgenomics.org
http://gabaldonlab.crg.es

Other Activities

Deathbase is a database of proteins involved in cell death.

Category:
Protein Analysis

Deathbase is a database of proteins involved in cell death. It compiles relevant data on the function, structure and evolution of proteins involved in apoptosis and other forms of cell death in several organisms. Information contained in this database is subjected to manual curation. You can contribute to maintain the DeathBase by editing the wikipage for any protein.

Website:

ETE (Environment for Tree Exploration) is a python programming toolkit that assists in the automated manipulation, analysis and visualization of hierarchical trees.

ETE (Environment for Tree Exploration) is a python programming toolkit that assists in the automated manipulation, analysis and visualization of hierarchical trees. Besides a broad set of tree handling options, ETE’s current version provides specific methods to analyze phylogenetic and clustering trees. It also supports large tree data structures, node annotation, independent editing and analysis of tree partitions, and the association of trees with external data such as multiple sequence alignments or numerical matrices. ETE first version was developed in collaboration with Dr. Joaquín Dopazo lab at Centro de Investigación Príncipe Felipe (CIPF).

Website:

MetaPhOrs is a public repository of phylogeny-based orthology and paralogy predictions for most species with fully-sequenced genomes.

Category:
Gene Analysis

MetaPhOrs is a public repository of phylogeny-based orthology and paralogy predictions for most species with fully-sequenced genomes.

Website:

PhylomeDB is a public database for complete collections of gene phylogenies (phylomes).

Category:
Gene Analysis

PhylomeDB is a public database for complete collections of gene phylogenies (phylomes). It allows users to interactively explore the evolutionary history of genes through the visualization of phylogenetic trees and multiple sequence alignments. Moreover, phylomeDB provides genome-wide orthology and paralogy predictions based on the analysis of the phylogenetic trees.

Website:

trimAl is a tool for the automated removal of spurious sequences or poorly aligned regions from a multiple sequence alignment It also includes readAl, a format converter between most alignment formats.

Category:
Sequence Analysis

trimAl is a tool for the automated removal of spurious sequences or poorly aligned regions from a multiple sequence alignment It also includes readAl, a format converter between most alignment formats.

Website: