Relationship between expression levels and gene product properties

Relationship between expression levels and gene product properties

We are interested in investigating the relationship between expression levels and gene product properties. In the figure, we show that a strong relationship exists between mRNA expression levels and aggregation rates of disease-related human proteins, whose kinetics was measured in vitro under near-physiological conditions. The coefficient of correlation between these two quantities is 0.97 (taken from Vendruscolo M and Tartaglia GG. Towards quantitative predictions in cell biology using chemical properties of proteins, Molecular BioSystems 2008, 4, 1170 – 1175).