Multicellular Systems Biology

Multicellular Systems Biology

Systems Biology

Multicellular Systems Biology

Group leader
j

Multicellular Systems Biology

Group leader
j

1997 PhD MRC National Institute for Medical Research at Mill Hill, London (UK). "Cis-regulatory mechanisms of the Hox genes in mouse development. Lab of Dr. Robb Krumlauf".
1997-1998 Postdoctoral on Xenopus development, University of Chile.
1998 MRC Human Genetics Unit, Edinburgh. Postdoctoral on computational approaches to study mouse limb development.
2001 Development of a 3D optical imaging technique and introduction of the term "Optical Projection Tomography", commercialised under the name Bioptonics.
2003 Group Leader in Edinburgh.
July 2006 ICREA Research Professor and Group Leader at the Centre de Regulació Genòmica, Barcelona (Spain).
May 2014 Coordinator of the Systems Biology Programme at the Centre de Regulació Genòmica, Barcelona (Spain).

Summary

The goal of our group is to bring together an interdisciplinary team of scientists to focus on the research of a particular complex system – development of the vertebrate limb. We aim to understand it both at the level of gene regulatory networks, and at the level of the physical interactions between cells and tissues.

To achieve this the group includes embryologists, computer scientists, imaging specialists and engineers. We thus aim to capture the whole process of understanding, from novel approaches for data-capture (live time-lapse OPT imaging) to finite-element simulations of the growing 3D structure and computer models of the gene networks responsible for pattern formation across the organ.

This combination of approaches is allowing us to address the following questions: What kinds of cellular movements are responsible for creating to correct 3D shape of the limb? How are these behaviours coordinated? How is the correct spatial pattern of gene expression controlled? What topology of gene regulatory network may be responsible for this complex phenomenon?