Dynamics of Living Systems

Dynamics of Living Systems

Systems Biology

Dynamics of Living Systems

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Dynamics of Living Systems

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2017 - Group Leader at the Centre for Genomic Regulation (CRG), Barcelona (Spain)
2013 - Independent Research Fellow, Harvard Medical School, Boston (USA)
2013 - Ph.D. in Systems Biology, Harvard University, Cambridge (USA)
2005 - B.S.E in Electrical Engineering, Princeton University, Princeton (USA)

Summary

We all age. Our bodies change so slowly over time that we often notice only by accident--something new in the mirror, a physical task we can no longer perform as quickly or for as long, an unfamiliar injury or an illness that lasts a little longer then it did last time. Later in life, these changes begin to cause illness and ultimately drive a rapid increase in the risk of death

Our research group seeks to link the macroscopic symptoms of aging to their molecular origins. In aging, a variety of mechanisms contribute at short, medium, and long time scales.  Furthermore, aging appears to involve a substantial degree of random chance.  To tackle this complexity, we incorporate techniques from a wide range of fields--molecular genetics, reliability engineering, bioinformatics, statistical physics, survival analysis, high-throughput imaging, and stochastic modelling. Focusing on C.  elegans as a model system, we seek to develop experimental and computational methods in parallel to help us characterize where, when, and why aging occurs, and how we might effectively intervene in its progression.

Insulin signalling diagram from Olivares-Reyes "Molecular and Cellular Endocrinology" 2009.  C. elegans schematic from wormatlas.org

We are currently building a high-throughput imaging cluster at the CRG that will allow us to run the equivalent of several large clinical trials a week using C. elegans as model patients.

Our group is expanding! Scientists at any stage in their careers interested in joining an interdisciplinary team should get in touch.

Aging is

  • A multi-scale problem, involving a large set of interacting degenerative changes observable across organs, tissues, cells, and the molecular components of cells. 
  • A multi-factorial process, influenced simultaneously by our diets, our environment, our behavior, and the genes we inherit from our parents
  • A slow-moving stochastic phenomenon in which chance appears to play a major role. 

News

Recent Publications: Google Scholar Page

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